منابع مشابه
Evolution in translational science: Whither the CTSAs?
Clinical and Translational Science Awards-funded institutions are naturally equipped to drive research on human phenotyping and, in turn, shape the practice of precision medicine in the clinic of the future.
متن کاملEvolution in translational science : Whither the CTSAs ?
C R E D IT : T IM F L A C H /G E T T Y Launched in 2006, the U.S. National Institutes of Health (NIH) Clinical and Translational Science Awards (CTSAs) program was designed to foster the integration of basic and clinical science so that fundamental discoveries might more readily be translated into new therapies, devices, or approaches to the prediction and management of disease—all directed tow...
متن کاملWhither Biological Database Research?
We consider how the landscape of biological databases may evolve in the future, and what research is needed to realize this evolution. We suggest today's dispersal of diverse resources will only increase as the number and size of those resources, driving the need for semantic interoperability even more strongly. Because the complexity of the questions biologists want answered automatically cont...
متن کاملTranslational Antidote Research: A Bedside to Bench Tale
Although antidote development should proceed in an orderly fashion from observation, to experimental and safety studies, to clinical trials, this sequence is not always precisely followed. The development of fomepizole as an antidote for toxic alcohol and glycol poisoning is an example of how this may not be the case. Interest in the development of fomepizole was spurred in the 1960s. Shortly t...
متن کاملTranslational Research
Treatment of dominantly inherited muscle disorders remains a difficult task considering the need to eliminate the pathogenic gene product in a body-wide fashion. We show here that it is possible to reverse dominant muscle disease in a mouse model of facioscapulohumeral muscular dystrophy (FSHD). FSHD is a common form of muscular dystrophy associated with a complex cascade of epigenetic events f...
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ژورنال
عنوان ژورنال: Journal of Orthopaedic Research
سال: 2008
ISSN: 0736-0266,1554-527X
DOI: 10.1002/jor.20678